Which hormone controls the secretion of hormones from the outer layer of the adrenal gland and may increase due to stress?

Adrenocorticotropin, also known as ACTH, is the hormone primarily responsible for stimulating the adrenal cortex, the outer layer of the adrenal gland, to secrete its hormones, notably cortisol. Cortisol plays a critical role in the body’s response to stress, aiding in the regulation of metabolism, inflammation, and the immune response. Under stress, the hypothalamus releases corticotropin-releasing hormone (CRH), which in turn prompts the pituitary gland to secrete ACTH. This increase in ACTH levels leads to heightened secretion of cortisol, which helps the body to effectively manage stressors. The role of ACTH in modulating the adrenal response is crucial for maintaining homeostasis during stressful situations, making it the correct answer in the context of hormone regulation and stress.